DOI:

10.37988/1811-153X_2023_1_12

Dental status of patients with cystic fibrosis (a review)

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Authors

  • M.A. Postnikov 1, PhD in Medical Sciences, full professor of the Therapeutic dentistry Department
    ORCID ID: 0000-0002-2232-8870
  • M.S. Saburova 1, assistant at the Therapeutic dentistry Department
    ORCID ID: 0000-0002-2220-6320
  • O.V. Kondratenko 1, PhD in Medical science, associate professor of the General and clinical microbiology, immunology and allergology Department
    ORCID ID: 0000-0002-7750-9468
  • A.M. Khamadeeva 1, PhD in Medical Sciences, full professor of the Pediatric dentistry and orthodontics Department
  • S.I. Vyrmaskin 1, PhD in Medical sciences, associate professor of the Dentistry department
    ORCID ID: 0000-0002-7778-0864
  • O.E. Simanovskaya 1, PhD in Medical sciences, associate professor of the Therapeutic dentistry Department
    ORCID ID: 0000-0002-7741-272X
  • A.V. Pashkova 1, resident at the Therapeutic dentistry Department
    ORCID ID: 0000-0002-7605-1766
  • 1 Samara State Medical University, 443001, Samara, Russia

Abstract

Cystic fibrosis is a genetically determined disease, which is based on a violation of salt metabolism. It is most common among people of European origin. This disease is multisystem, the gastrointestinal tract, pancreas, liver, respiratory tract, salivary and sweat glands, as well as the reproductive system are affected. In the 1950—1960s cystic fibrosis was considered a fatal disease, the vast majority of patients did not live to 5 years. Currently, due to the continuous improvement of treatment and rehabilitation methods, the duration and quality of life of people with this pathology has increased significantly. However, in more than 90% of cases, the development of severe complications due to chronic insufficiency of the respiratory system is observed. A broad evidence base confirms the negative impact of chemical and metabolic disorders accompanying diseases and pathological conditions on the condition of organs and tissues of the oral cavity. Violation of water-salt metabolism, damage to the salivary glands, prolonged courses of antibiotic, hormone and enzyme therapy for cystic fibrosis are reflected in the level of dental health of these patients. Long courses of antibacterial therapy are the cause of exfoliative and angular cheilitis, candidiasis of the oral mucosa, the presence of xerostomia and hemorrhages on the oral mucosa become a manifestation of salivary gland insufficiency, a number of patients with cystic fibrosis have a combination of several signs of tongue pathology, non-carious lesions of hard dental tissues and periodontal diseases are widespread. >. Despite the proven fact of the presence of oral diseases in patients with cystic fibrosis, the issues of diagnosis, identification of risk factors for their development are not given due attention.

Key words:

cystic fibrosis, oral mucosa, gingivitis, caries, nonspecific resistance of the oral cavity

For Citation

[1]
Postnikov M.A., Saburova M.S., Kondratenko O.V., Khamadeeva A.M., Vyrmaskin S.I., Simanovskaya O.E., Pashkova A.V. Dental status of patients with cystic fibrosis (a review). Clinical Dentistry (Russia).  2023; 26 (1): 12—17. DOI: 10.37988/1811-153X_2023_1_12

References

  1. Klimova B., Kuca K., Novotny M., Maresova P. Cystic fibrosis revisited a review study. Med Chem. 2017; 13 (2): 102—109. PMID: 27292156
  2. Scotet V., L'Hostis C., Férec C. The changing epidemiology of cystic fibrosis: incidence, survival and impact of the CFTR gene discovery. Genes (Basel). 2020; 11 (6): 589. PMID: 32466381
  3. Hangül M., Pekcan S., Köse M., Acıcan D., Şahlar T.E., Erdoğan M., Kendirci M., Güney D., Öznavruz H., Demir O., Ercan Ö., Göçlü F. The incidence of cystic fibrosis in the central region of Anatolia in Turkey between 2015 and 2016. Balkan Med J. 2019; 36 (3): 179—183. PMID: 30592194
  4. Parker-McGill K., Nugent M., Bersie R., Hoffman G., Rock M., Baker M., Farrell P.M., Simpson P., Levy H. Changing incidence of cystic fibrosis in Wisconsin, USA. Pediatr Pulmonol. 2015; 50 (11): 1065—1072. PMID: 26258862
  5. Elborn J.S. Cystic fibrosis. Lancet. 2016; 388 (10059): 2519—2531. PMID: 27140670
  6. Sergienko D.F., Bashkina O.A., Galimzyanov H.M., Belopasova N.A. The peculiarities of clinical manifestations of mucoviscidosis in children. Astrakhan Medical Journal. 2010; 3: 49—53 (In Russ.). eLIBRARY ID: 15210124
  7. Lipov D.S., Skvortsov V.V., Lukina M.A., Gorshenina M.V., Lugovkina A.A. Cystic fibrosis. The Nurse. 2017; 4: 22—30 (In Russ.). eLIBRARY ID: 29371812
  8. Krasovskiy S.A., Adyan T.A., Amelina E.L., Sergienko D.F., Shadrina V.V., Guschin M.Yu., Zonenko O.G., Makarova M.A. Cystic Fibrosis: Some Issues of Epidemiology and Genetics. Practical pulmonology. 2019; 4: 45—50 (In Russ.). eLIBRARY ID: 42699182
  9. Evstratov A.A., Cheremisin A.E., Abbazov R.R., Sabirova D.R. Cystic fibrosis as a multisided problem. Literature review and clinical examples. Practical medicine. 2019; 6-1: 11—14 (In Russ.). eLIBRARY ID: 41461022
  10. Molina-García A., Castellanos-Cosano L., Machuca-Portillo G., Posada-de la Paz M. Impact of rare diseases in oral health. Med Oral Patol Oral Cir Bucal. 2016; 21 (5): e587—94. PMID: 27475682
  11. Javaid M.A., Ahmed A.S., Durand R., Tran S.D. Saliva as a diagnostic tool for oral and systemic diseases. J Oral Biol Craniofac Res. 2016; 6 (1): 66—75. PMID: 26937373
  12. Eick S. Biofilms. Monogr Oral Sci. 2021; 29: 1—11. PMID: 33427230
  13. Matczuk J., Żendzian-Piotrowska M., Maciejczyk M., Kurek K. Salivary lipids: A review. Adv Clin Exp Med. 2017; 26 (6): 1021—1029. PMID: 29068606
  14. Mantovani R.P., Sandri A., et al. Toothbrushes may convey bacteria to the cystic fibrosis lower airways. J Oral Microbiol. 2019; 11 (1): 1647036. PMID: 31489126
  15. Willis J.R., Saus E., et al. Citizen-science based study of the oral microbiome in Cystic fibrosis and matched controls reveals major differences in diversity and abundance of bacterial and fungal species. J Oral Microbiol. 2021; 13 (1): 1897328. PMID: 34104346
  16. Herman K., Kowalczyk-Zając M., Pytrus T. Oral cavity health among cystic fibrosis patients: Literature overview. Adv Clin Exp Med. 2017; 26 (7): 1147—1153. PMID: 29211365
  17. Coffey N., O'Leary F., Burke F., Roberts A., Hayes M. Periodontal and oral health status of people with Cystic Fibrosis: a systematic review. J Dent. 2020; 103: 103509. PMID: 33129998
  18. Mantovani R.P., Sandri A., et al. Longitudinal monitoring of sinonasal and oral bacterial reservoirs to prevent chronic lung infection in people with cystic fibrosis. ERJ Open Res. 2020; 6 (3): 00115—2020. PMID: 32864382
  19. Harutyunyan S.A., Simonyan K.G., Mkrtchyan N.M., Kashirskaya N.Yu., Libik M., Macek M. Sialadenitis in Cystic Fibrosis: Case Report. Doctor.Ru. 2020; 10: 66—68 (In Russ.). eLIBRARY ID: 44313959
  20. Vyrmaskin S.I., Trunin D.A., Postnikov M.A., Shukhorova Yu.A., Simanovskaya O.E., Navasardyan N., Saburova M.S., Konnov V.V., Domenyuk D.A. Morphological features of wound process in patients with inflammatory and destructive periodontal diseases in case of diabetes mellitus. Archiv EuroMedica. 2021; 6: 100—106. eLIBRARY ID: 47289304
  21. Pawlaczyk-Kamieńska T., Śniatała R., et al. Periodontal status and subgingival biofilms in cystic fibrosis adults. Pol J Microbiol. 2019; 68 (3): 377—382. PMID: 31880883
  22. Rivas Caldas R., Le Gall F., Revert K., Rault G., Virmaux M., Gouriou S., Héry-Arnaud G., Barbier G., Boisramé S. Pseudomonas aeruginosa and periodontal pathogens in the oral cavity and lungs of cystic fibrosis patients: a case-control study. J Clin Microbiol. 2015; 53 (6): 1898—907. PMID: 25854483
  23. Peker S., Kargul B., Tanboga I., Tunali-Akbay T., Yarat A., Karakoc F., Ersu R., Dagli E. Oral health and related factors in a group of children with cystic fibrosis in Istanbul, Turkey. Niger J Clin Pract. 2015; 18 (1): 56—60. PMID: 25511345
  24. Pawlaczyk-Kamieńska T., Borysewicz-Lewicka M., Śniatała R. Periodontal condition and periodontal risk assessment in adult patients with cystic fibrosis. Ann Agric Environ Med. 2020; 27 (2): 235—239. PMID: 32588599
  25. Pawlaczyk-Kamieńska T., Borysewicz-Lewicka M., Śniatała R., Batura-Gabryel H., Cofta S. Dental and periodontal manifestations in patients with cystic fibrosis A systematic review. J Cyst Fibros. 2019; 18 (6): 762—771. PMID: 30473190
  26. da Silva Modesto K.B., de Godói Simões J.B., de Souza A.F., Damaceno N., Duarte D.A., Leite M.F., de Almeida E.R. Salivary flow rate and biochemical composition analysis in stimulated whole saliva of children with cystic fibrosis. Arch Oral Biol. 2015; 60 (11): 1650—4. PMID: 26351748
  27. Tkachenko M., Fomenko Y., Bondarenko A., Shevchuk V., Odushkina N., Nazaryan R. The use of miramistin in the treatment of chronic gingivitis in children with cystic fibrosis. Pharmacologyonline. 2021; 3: 398—404. eLIBRARY ID: 48783723
  28. Saburova M.S., Kondratenko O.V. Oral cavity as the locus of infection in cystic fibrosis. Problems in Medical Mycology . 2022; 2: 125 (In Russ.). eLIBRARY ID: 48666195
  29. Samsonova M.V., Chernyaev A.L., Krasovsky S.A., Amelina E.L., Usacheva M.V. Pathology of cystic fibrosis in adult patients. Clinical and Experimental Morphology. 2017; 4 (24): 31—37 (In Russ.). eLIBRARY ID: 32231631
  30. Manovitskaya N.V., Harevich O.N., Borodina G.L. The method of determining the severity of clinical and functional status of patients with cystic fibrosis. Medical Journal. 2014; 1 (47): 87—89 (In Russ.). eLIBRARY ID: 21304329
  31. Harrington N., Barry P.J., Barry S.M. Dental treatment for people with cystic fibrosis. Eur Arch Paediatr Dent. 2016; 17 (3): 195—203. PMID: 27146508
  32. Khamraev Kh.T., Shavazi N.M., Rustamov M.R. Features of the course and complications of cystic fibrosis depending on age. Science, Education and Culture. 2020; 6 (50): 76—78 (In Russ.). eLIBRARY ID: 43099498
  33. Vinokurova L.V., Baimakanova G.E., et al. Functional insufficiency of the pancreas and the metabolic activity of the microbiota in cystic fibrosis adults patients. Therapeutic Archive. 2018; 10: 84—88 (In Russ.). eLIBRARY ID: 36298288
  34. Hildebrandt T., Zawilska A., et al. Estimation of proinflammatory factors in the saliva of adult patients with cystic fibrosis and dental caries. Medicina (Kaunas). 2020; 56 (11): 612. PMID: 33202617
  35. Alkhateeb A.A., Mancl L.A., et al. Unstimulated saliva-related caries risk factors in individuals with cystic fibrosis: A cross-sectional analysis of unstimulated salivary flow, pH, and buffering capacity. Caries Res. 2017; 51 (1): 1—6. PMID: 27846621
  36. Gelzo M., Iacotucci P., et al. Impaired ratio of unsaturated to saturated non-esterified fatty acids in saliva from patients with cystic fibrosis. Diagnostics (Basel). 2020; 10 (11): 915. PMID: 33171650
  37. Castaldo A., Iacotucci P., et al. Salivary cytokines and airways disease severity in patients with cystic fibrosis. Diagnostics (Basel). 2020; 10 (4): 222. PMID: 32326546
  38. Abrami M., Ascenzioni F., et al. A novel approach based on low-field NMR for the detection of the pathological components of sputum in cystic fibrosis patients. Magn Reson Med. 2018; 79 (4): 2323—2331. PMID: 28833401
  39. Chin M., Brennan A.L., Bell S.C. Emerging nonpulmonary complications for adults with cystic fibrosis: Adult cystic fibrosis series. Chest. 2022; 161 (5): 1211—1224. PMID: 34774529
  40. Sinha A., Southern K.W. Cystic fibrosis transmembrane conductance regulator-related metabolic syndrome/cystic fibrosis screen positive, inconclusive diagnosis (CRMS/CFSPID). Breathe (Sheff). 2021; 17 (3): 210088. PMID: 35035555
  41. Mingora C.M., Flume P.A. Pulmonary complications in cystic fibrosis: past, present, and future: adult cystic fibrosis series. Chest. 2021; 160 (4): 1232—1240. PMID: 34147501
  42. Regard L., Lafoeste H., Martin C., Chassagnon G., Burgel P.R. [Ageing with cystic fibrosis: Classical and emerging comorbidities in adults with cystic fibrosis]. Rev Pneumol Clin. 2018; 74 (5): 279—291 (In French). PMID: 30316653
  43. Furman E.G., Shadrina V.V., Maksimycheva T.Yu., Sherman V.D., Kondratyeva E.I. Cost of therapy for cystic fibrosis in different age groups with consideration to the respiratory tract infection and complications. Russian Pulmonology. 2021; 2: 238—249 (In Russ.). eLIBRARY ID: 45604409
  44. Krasovskii S.A., Kashirskaya N.Yu., Usacheva M.V., Amelina E.L., Chernyak A.V., Naumenko Zh.K. Influence of the age of the diagnosis and the beginning of specific therapy on main clinical and laboratory manifestations of a disease in patients with cystic fibrosis. Current Pediatrics (Moscow). 2014; 2: 36—43 (In Russ.). eLIBRARY ID: 21467353
  45. Almeslet A., Alnamlah S., Alanzan L., Aldriwesh R., AlWehaiby S. Role of salivary biomarkers in cystic fibrosis: a systematic review. Biomed Res Int. 2022; 2022: 5818840. PMID: 35097122
  46. Kondratyeva E.I., Amelina E.L., Chernukha M.Yu., Sherman V.D., Krasovskiy S.A., Kashirskaya N.Yu., Simonova O.I., Avdeev S.N., Namazova-Baranova L.S., Gembitskaya T.E., Kutsev S.I. Review of clinical guidelines “Cystic fibrosis” (2020). Russian Pulmonology. 2021; 2: 135—147 (In Russ.). eLIBRARY ID: 45604399
  47. Pawlaczyk-Kamieńska T., Borysewicz-Lewicka M., et al. Oral care recommendation for cystic fibrosis patients-recommendation for dentists. J Clin Med. 2022; 11 (10): 2756. PMID: 35628882
  48. Frías J.P., Ruiz E.P., López Castillo M.D.C., García P.C. The History of cystic fibrosis. Open Journal of Pediatrics and Child Health. 2019; 4: 001—006. DOI: 10.17352/ojpch.000015
  49. Kashirskaya N.Yu., Kapranov N.I., Vasilieva Yu.I. Difficulties of diagnosing mucoviscidosis. Current Pediatrics (Moscow). 2005; 1: 89—92 (In Russ.). eLIBRARY ID: 18023076
  50. Goryainova A.V., Krasovsky S.A., Semykin S.Yu., Donnikov A.E. Phenotypic manifestations of four newly identified mutations of the cftr gene. Medical News of North Caucasus. 2020; 2: 182—185 (In Russ.). eLIBRARY ID: 43162707

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Received

September 20, 2022

Accepted

February 19, 2023

Published on

March 22, 2023