DOI:

10.37988/1811-153X_2022_2_34

Association of recurrent aphthous stomatitis with an iron, vitamin B12 and folic acid deficiency: A clinical case

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Authors

  • L.A. Aksamit 1, PhD in Medical Sciences, associate professor of the Pain management in dentistry Department
    ORCID ID: 0000-0002-1911-525X
  • G.S. Runova 1, PhD in Medical Sciences, associate professor of the Periodontology Department
    ORCID ID: 0000-0002-3545-6353
  • V.V. Luzina 1, PhD in Medical Sciences, associate professor of the Maxillofacial and plastic surgery Department
    ORCID ID: 0000-0002-3159-6818
  • M.A. Tsvetkova 1, PhD in Medical Sciences, dentist
    ORCID ID: 0000-0003-2183-1623
  • A.A. Babanina 1, dentist
  • 1 Moscow State University of Medicine and Dentistry, 127473, Moscow, Russia

Abstract

Recurrent aphthous stomatitis (RAS) is a common disease of the oral mucosa. The etiopathogenesis of RAS is associated with various factors that change the immunological response. Many authors connected RAS development with anemia due to the vitamin B12, folic acid and iron deficiency. The aim of the study is clinical observation and examination of patients with RAS in order to identify vitamin B12, iron and folic acid deficiency.
Material and methods.
12 patients with a clinical picture of RAS (6 women and 6 men aged 20-44 years) were examined for possible anemia and blood concentration of vitamin B12, folic acid and iron.
Results.
Blood tests showed signs of anemia in 7 people due to iron deficiency (in 3), vitamin B12 (in 3) and folic acid (in 1). In 5 patients, there were no abnormalities in blood counts. All patients with RAS and anemia were referred to a gastroenterologist. All patients received local symptomatic treatment, including analgesics, anti-inflammatory and epithelial agents. Discussion. In the literature, the association of RAS with gastrointestinal tract diseases (celiac disease, Crohn’s disease, etc.) was most often noted, which is currently explained by impaired absorption of substances such as iron, vitamins B1, B2, B6, B12, folic acid.
Conclusion.
A dentist treating patients with RAS, should include a general clinical blood test and tests for the content of vitamin B12, folic acid and iron in the diagnostic plan. If anemia is detected, patients should be referred to gastroenterologist and hematologist. Dental treatment is symptomatic.

Key words:

recurrent aphthous stomatitis, anemia, folic acid deficiency, vitamin B12 deficiency, iron deficiency

For Citation

[1]
Aksamit L.A., Runova G.S., Luzina V.V., Tsvetkova M.A., Babanina A.A. Association of recurrent aphthous stomatitis with an iron, vitamin B12 and folic acid deficiency: A clinical case. Clinical Dentistry (Russia).  2022; 25 (2): 34—37. DOI: 10.37988/1811-153X_2022_2_34

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Received

April 20, 2022

Published on

June 1, 2022