DOI:

10.37988/1811-153X_2026_1_102

Clinical rationale for the use of a fermented phytocomplex in the complex therapy of erosive and ulcerative forms of oral lichen planus

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Authors

  • A.Kh. Sheregov 1, PhD in Medical Sciences, assistant professor of the Dentistry and maxillofacial surgery Institute
    ORCID: 0009-0008-0384-7967
  • A.O. Balkarov 2, PhD in Medical Sciences, dentist
  • M.Sh. Mustafaev 1, Doctor of Science in Medicine, professor, director of the Dentistry and maxillofacial surgery Institute
    ORCID: 0000-0002-4042-9421
  • O.M. Gendugova 1, PhD in Medical Sciences, associate professor of the Dentistry and maxillofacial surgery Institute
    ORCID: 0000-0001-5541-4989
  • Zh.A. Abregova 1, assistant of the Dentistry and maxillofacial surgery Institute
    ORCID: 0009-0008-7665-3581
  • B.S. Erokova 1, assistant of the Dentistry and maxillofacial surgery Institute
    ORCID: 0009-0001-1223-8089
  • I.V. Tlupov 1, assistant of the Dentistry and maxillofacial surgery Institute
    ORCID: 0009-0003-4474-5434
  • 1 Kabardino-Balkarian State University, 360004, Nalchik, Russia
  • 2 “Smile” Dental Clinic, 360000, Nalchik, Russia

Abstract

A survey and comprehensive (general and local) treatment of patients with erosive-ulcerative form of lichen planus of the oral mucosa were carried out. The scheme of comprehensive treatment of patients of group 1 included local application of vitamin A in the form of applications on the affected areas, and patients of group 2 received applications of a fermented complex of plant origin instead of vitamin A. Thus, as a result of treatment, the group with a fermented phyto-complex as part of the complex therapy showed higher clinical efficiency, which was expressed in a rapid decrease in inflammatory phenomena, epithelization of erosions and a decrease in subjective feelings of patients.

Key words:

fermented phytocomplex, oral mucosa lichen planus

For Citation

[1]
Sheregov A.Kh., Balkarov A.O., Mustafaev M.Sh., Gendugova O.M., Abregova Zh.A., Erokova B.S., Tlupov I.V. Clinical rationale for the use of a fermented phytocomplex in the complex therapy of erosive and ulcerative forms of oral lichen planus. Clinical Dentistry (Russia).  2026; 29 (1): 102—105. DOI: 10.37988/1811-153X_2026_1_102

References

  1. Titarenko M.A. Clinical and diagnostic features of oral mucosal lichen planus against the background of carbohydrate metabolism disorders: master’s thesis abstract. Tomsk: Siberian State Medical University, 2019. P. 3 (In Russian).
  2. González-Moles M.Á., Warnakulasuriya S., González-Ruiz I., González-Ruiz L., Ayén Á., Lenouvel D., Ruiz-Ávila I., Ramos-García P. Worldwide prevalence of oral lichen planus: A systematic review and meta-analysis. Oral Dis. 2021; 27 (4): 813—828. PMID: 32144836
  3. Warnakulasuriya S., Kujan O., Aguirre-Urizar J.M., Bagan J.V., González-Moles M.Á., Kerr A.R., Lodi G., Mello F.W., Monteiro L., Ogden G.R., Sloan P., Johnson N.W. Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer. Oral Dis. 2021; 27 (8): 1862—1880. PMID: 33128420
  4. Kostina I., Yepishova A., Griroriev S., Chernyshova N., Sorokoumova D. Pre-cancer diseases of the mucous membrane of the oral cavity, red border of the lips and facial skin. Ekaterinburg: Tirazh, 2019. 84 p. (In Russian). eLIBRARY ID: 41126545
  5. Mikhalchenko A.V., Fedotova Yu.M., Mikhalchenko V.F., Medvedeva E.A. Erosive-ulcerative form red flat lichen planus: prospects for a new approach to therapy and prognosis. Scientific Review. Medical sciences. 2016; 3: 80—83 (In Russian). eLIBRARY ID: 26682681
  6. Rashid A., Warnakulasuriya S. The use of light-based (optical) detection systems as adjuncts in the detection of oral cancer and oral potentially malignant disorders: a systematic review. J Oral Pathol Med. 2015; 44 (5): 307—28. PMID: 25183259
  7. Dyachenko S.V. Clinical and organizational features of monitoring and treatment of patients with oral lichen planus: master’s thesis. Volgograd: Volgograd State Medical University, 2022. P. 20 (In Russian).
  8. Yang X.Y., Li X.Z., Zhang S.N. Metabolomics analysis of oral mucosa reveals profile perturbation in reticular oral lichen planus. Clin Chim Acta. 2018; 487: 28—32. PMID: 30218656
  9. Guryevskaya O.A. Optimization of diagnosis and treatment of oral mucosal lichen planus: master’s thesis. Ufa: Bashkir State Medical University, 2023. P. 12 (In Russian).
  10. Tlish M.M., Osmolovskaya P.S. Lichen planus ruber, current therapy: a systematic review. Kuban Scientific Medical Bulletin. 2021; 2: 104—119 (In Russian)]. DOI: 10.25207/1608-6228-2021-28-2-104-119
  11. Mikhal’chik E.V., Ivanova A.V., Anurov M.V., Titkova S.M., Pen’kov L.Y., Kharaeva Z.F., Korkina L.G. Wound-healing effect of papaya-based preparation in experimental thermal trauma. Bull Exp Biol Med. 2004; 137 (6): 560—2. PMID: 15455084
  12. Sheregov A.Kh., Kharaeva Z.F., Mustafaev M.Sh., Korkina L.G., Batyrbekova F.R., Agnokova T.Kh. Effectiveness of using fermented herbal preparation in complex therapy of periodontitis developed as an orthodontic treatment complication. Russian Open Medical Journal. 2021; 4: 425. DOI: 10.15275/rusomj.2021.0425
  13. Osato J.A., Korkina L.G., Santiago L.A., Afanas’ev I.B. Effects of bio-normalizer (a food supplementation) on free radical production by human blood neutrophils, erythrocytes, and rat peritoneal macrophages. Nutrition. 1995; 11 (5 Suppl): 568—72. PMID: 8748224

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Received

November 25, 2025

Accepted

February 20, 2026

Published on

March 31, 2026