DOI:

10.37988/1811-153X_2024_4_140

Therapeutic efficacy of bacteriophage-based gel in the treatment of peri-implantitis mucositis

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Authors

  • D.Z. Tagizade 1, assistant at the Department of additional education in dentistry specialties
    ORCID: 0000-0002-2143-505X
  • Yu.V. Parshin 2, PhD in Medical Sciences, assistant professor of the Prosthodontics, materials science and orthodontics Department
    ORCID: 0000-0002-7075-2377
  • V.N. Trezubov 2, Doctor of Science in Medicine, full professor of the Prosthodontics, materials science and orthodontics Department
    ORCID: 0000-0003-0532-5632
  • R.A. Rozov 2, 3, Doctor of Science in Medicine, professor of the Prosthodontics, materials science and orthodontics Department; chief physician
    ORCID: 0000-0001-5804-9497
  • 1 Yaroslav-the-Wise Novgorod State University, 173003, Veliky Novgorod, Russia
  • 2 Pavlov University, 197022, Saint-Petersburg, Russia
  • 3 Municipal dental clinic no. 33, 197341, Saint-Petersburg, Russia

Abstract

Inflammation of peri-implant tissues remains a current problem in orthopaedic dentistry. At the same time, there is no unified and clear opinion on the treatment of peri-implant mucositis. The aim of the study was to perform a clinical evaluation of the effectiveness of the gel containing bacteriophages “Phagodent” in the complex therapy of initial peri-implant mucositis.
Materials and methods.
A total of 62 patients aged between 38 and 62 years (mean age — 50.9±1.5 years) were included in the study group. Their initial peri-implant mucositis was treated mainly with the gingival gel “Phagodent”. Clinical, radiological, clinical-laboratory and clinical-sociological examination tests were used to analyse the state of health of the peri-implant tissues.
Results.
 In 2—3 weeks of treatment only one person (2%) remained with separate signs of inflammation. Only after 3 months did they appear in the form of periodic minor bleeding. They were stopped by repeated applications of “Phagodent” in combination with the “OKI” rinse containing ketoprofen lysine. On admission, 94% (58 patients) had mild to moderate peri-implant cuff bleeding. At 3 months after treatment the bleeding was mild. The plaque index of implants and prostheses showed average moderate values. After a course of complex therapy with the use of “Phagodent”, it decreased significantly. Clinical and social author’s methods of expert evaluation survey TAPATR and patient’s self-evaluation of peri-implant tissues condition PARTAT showed reliable improvement (p<0.01) of health level and its maintenance 3 months after treatment (p<0.02).
Conclusion.
The use of “Phagodent” gel with bacteriophages was very successful, as by the end of the first week of application, the symptoms of inflammation completely disappeared in the overwhelming majority of patients (61 people; 98%), were partially reduced in one patient (2%) and were completely eliminated in him during the repeated course of treatment. Such a high percentage of suppression testifies to the great effectiveness of “Phagodent” gel, and the rapid elimination of inflammatory symptoms (5—7 days) testifies to the undoubted effectiveness of this preparation in the treatment of initial peri-implant mucositis.

Key words:

peri-implant mucositis, gel with bacteriophages, prosthesis, implant

For Citation

[1]
Tagizade D.Z., Parshin Yu.V., Trezubov V.N., Rozov R.A. Therapeutic efficacy of bacteriophage-based gel in the treatment of peri-implantitis mucositis. Clinical Dentistry (Russia).  2024; 27 (4): 140—146. DOI: 10.37988/1811-153X_2024_4_140

References

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Received

April 5, 2024

Accepted

November 10, 2024

Published on

December 17, 2024